PFAM catalyzed enantioselective diethylzinc addition to imines
نویسندگان
چکیده
منابع مشابه
Enantioselective rhodium-catalyzed addition of potassium alkenyltrifluoroborates to cyclic imines.
Chiral α-branched allylic amines are important building blocks for organic synthesis, and several catalytic asymmetric methods have been developed for their synthesis. For example, enantioselective metal-catalyzed amination of allylic electrophiles 1 , 2 , 3 ] and rearrangement of allylic imidates have proven to be highly effective. An alternative approach to chiral allylic amines that can be a...
متن کاملCatalytic enantioselective addition to imines.
Chiral nitrogen-containing compounds are widely distributed in nature and include many biologically important molecules (Chart 1). In these compounds, the nitrogen-containing units are known to play important roles for their bioactivities. For the synthesis of these chiral nitrogen-containing building blocks, use of imines as electrophiles is the most promising and convenient route.1 While many...
متن کاملEnantioselective Addition of Diethylzinc to Aldehydes Catalyzed by a Titanate Complex with a Chiral Tetradentate Ligand.
The addition of dialkylzincs to aldehydes is one of the most widely studied carbon-carbon bond-forming reactions. Many systems reported to date use amino alcohols as ligands and zinc complexes as catalysts.1 The asymmetric version of this alkylation reaction can also be catalyzed by chiral titanate complexes2-4 (e.g., TADDOLs2 and chiral sulfonamides3). We have recently studied a titanate compl...
متن کاملCopper-Catalyzed Enantioselective Addition of Styrene-Derived Nucleophiles to Imines Enabled by Ligand-Controlled Chemoselective Hydrocupration
The copper-catalyzed intermolecular enantioselective addition of styrenes to imines has been achieved under mild conditions at ambient temperature. This process features the use of styrenes as latent carbanion equivalents via the intermediacy of catalytically generated benzylcopper derivatives, providing an effective means for accessing highly enantiomerically enriched amines bearing contiguous...
متن کاملCopper-catalyzed enantioselective 1,4-addition of alkyl groups to N-sulfonyl imines.
In copper(I)/phosphoramidite-catalyzed asymmetric 1,4-additions of dialkylzinc, N-sulfonyl imines are more reactive and furnish higher enantiomeric excesses than the respective cycloalk-2-enones. This enables formation of a quaternary stereocenter as well as a cis-selective addition to an imine derived from 5-methylcyclohex-2-enone. The 1,4-adducts can be transformed in stereodivergent reductio...
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ژورنال
عنوان ژورنال: TURKISH JOURNAL OF CHEMISTRY
سال: 2015
ISSN: 1300-0527,1303-6130
DOI: 10.3906/kim-1410-29